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KMID : 0861020030180040127
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Korea Journal of Herbology
2003 Volume.18 No. 4 p.127 ~ p.134
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Beneficial Effect of Nodus Nelumbinis Rhizomatis Extract on Cisplatin-Induced Kidney Toxicity in Rats
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Abstract
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Objectives : The present study was carried out to determine if Nodus Nelumbinis Rhizomatis extractWRE) exerts beneficial effect against the renal failure in rats. IWE was selected in the basis of invigorating kidney-QI which can eliminate pathogens.
Methods : Rats were pretreated with NRE orally for 7 days, followed by cisplatin injection(5me/kg body weight). Cisplatin injection caused an increase in semm creatinine level, and BUN too.
Results : The main cause of cisplatin-induced renal failure was thought to be the increase of lipid peroxidation of renal tissues. And cisplatin administration reduced the activation of GSH and Na-K-ATPase. But "RE treatment exerts beneficial effect against the renal failure by decreasing serum level of creatinine and BUN. Na-K-ATPase activity in renal cortical tissues increased, too.
Conclusion : These results indicate that lipid peroxidation plays a critical role in cisplatin-induced acute renal failure. NRE exerts the protective effect against acute renal failure induced by cisplatin, and its effect may be attributed to an antioxidant action.
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